What is Matrixyl Synthe 6?

MISMO's skincare range consists of natural bases with specialty active ingredients. One of these specialty actives is known as MATRIXYL SYNTHE 6 ®. Not many companies use this because of the high cost. However, MISMO prides itself on using high quality ingredients regardless of cost. All ingredients MISMO use have a purpose and produce results, and given MATRIXYL SYNTHE 6 formidable anti-ageing capabilities, it was an easy choice to include in our Anti-Ageing range.

MATRIXYL SYNTHE 6 ® contains bio peptides derived from amino acids.

Wondering what a peptide is?

A peptide is a compound consisting of two or more amino acids linked in a chain.

Meanwhile, Amino acids are essentially the building blocks of protein. There are 20 amino acids used in our body. When you link together a few of these amino acids, you form a peptide and subsequently when you link thousands of them together, you get a protein. Makes sense?

So what exactly does MATRIXYL SYNTHE 6 ® do?

Put simply, it stimulates major constituents of the skin matrix including Collagen and Hyaluronic Acid. In clinical tests, Matrixyl Synthe 6 ® reduced the surface area occupied by deep wrinkles by 44.9% on average. It encouraged skin tissue to restore itself to a more youthful strength while promoting deep tissue repair. Collagen and elastin production was accelerated, skin appeared softer and firmer, and elasticity was significantly improved.

Interestingly, in 2015 Matrixyl was the winner of the 25 Years of Innovation Award which recognises products that have had the greatest impact on the Personal Care ingredients market in the last quarter-century. Matrixyl was considered as a breakthrough in the Cosmetic industry as voted for by over a thousand show visitors and a panel of industry experts.
If this is the response that Matrixyl was given then you could only imagine the benefits your skin would be receiving from MATRIXYL SYNTHE 6 ®.

You'll find MATRIXYL SYNTHE 6 ® in MISMO's Rejuvenating Serum - An anti-ageing serum that is unrivalled in its abilities to reduce lines and wrinkles. Including 50% Hyaluronic Acid together with MATRIXYL SYNTHE 6 ®, MSM and Organic Aloe Vera, MISMO's Rejuvenating Serum delivers results quickly. 

Rejuvenating Serum
A potent formulation of hyaluronic acid, MSM, aloe vera and tripeptides from Matrixyl Synthe'6, formulated to give you a silky, hydrated and more youthful-looking complexion and repair age-related damage.

MISMO Body Care offers a range of Anti-Ageing skincare products.

Anti-Ageing Bundle

All of our skincare and most bundles are available in trial sizes to give you the chance to find what works best for your skin type. If you have any questions, please do reach out to us as we are happy to assist you. 



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MISMO MSM - 440g / Ultra-Pure Distilled - Pain Relief
MISMO MSM - Pain Relief
MISMO MSM - Pain Relief
MISMO MSM - 850g / Ultra-Pure Distilled - Pain Relief
MISMO MSM - Pain Relief
MISMO MSM - Pain Relief
MISMO MSM - Pain Relief


Regular price$38.00
Tax included. Shipping free Aus/NZ over A$150 (see info below).


MSM is known to be highly effective in joint health, muscle recovery, sports nutrition, immune support, and healthy ageing. 

What is MSM?

MSM (Methyl Sulphonyl Methane or Dimethyl Sulfone) is an organic sulphur compound found in all living organisms. It is the purest and most bio-available form of sulphur, one of the essential minerals crucial to life and the regeneration of cells. MSM has traditionally been taken as a food supplement to increase joint health for flexibility and mobility, as well as for strong hair and nails, beautiful skin, and other health conditions from leaky gut syndrome to mild arthritis, osteoporosis, and psoriasis. 

Why do we need to supplement with MSM?

Natural MSM is largely destroyed when our food is processed and can be lost entirely when foods and ingredients are stored for a long period of time. MSM bonds with moisture, so any food which undergoes any sort of dehydration will lack its natural MSM.

For these reasons, and because MSM is so critical for almost every athletic function in active bodies, it is important to consistently supplement with a quality MSM nutritional supplement 

How does MSM work at the cellular level?

Collagen is the principal structural protein holding the skin together and is largely responsible for the skin’s mechanical properties.  Sulphur is integral to the production of collagen and elastin, and MSM is a source of organic Sulphur. 

Approximately half of the body's sulphur content is found in the skin, muscles, cartilage and bones.

How can MSM benefit your skin, hair and nails?

  • Protecting collagen against collagen degrading enzymes
  • Reducing fine lines and wrinkles by boosting collagen and elastin production
  • Boosting the natural production of Glutathione, one of the body's key anti-oxidants ... as an anti-oxidant, MSM will boost the immune system and reduce pigmentation and cellular damage
  • Acting as an anti-inflammatory agent by reducing the production of cytokines (compounds that cause inflammation)
  • Maintaining skin cell membrane flexibility and permeability, promoting an efficient exchange of nutrients and waste products to help keep skin clear
  • Helping to maintaining the body's pH balance

How can MSM help with joint health and support? 

MSM has powerful anti-inflammatory properties and can be used as a natural alternative to help reduce pain from mild arthritis and osteoarthritis related symptoms.

How does MISMO MSM help with exercise recovery?

Our muscles, skin, bones, organs, and connective tissue all rely on sulphur and without it our bodies can not function properly.  MSM is an important nutritional supplement for anyone living an active lifestyle, as it delivers the sulphur and methyl nutrients which are key to the structure of healthy cells in muscle and connective tissue.

MSM is valued by bodybuilders, strength, and power athletes because it supports healthy and flexible cell structures and can help reduce the inflammation of muscle tissue and can offset muscle soreness and joint pain caused by inflammation.

Where is MSM found and how is it manufactured?

MSM is found in the fluid and tissue of all living organisms. It is present in a variety of foods including raw vegetables, eggs, milk and fish, but is lost through cooking and food processing. One of the richest natural supplies is pine trees and cabbage.

Although MSM is abundant in nature, even the richest natural sources only provide MSM in the level of several parts per million. Commercial extraction of MSM from trees is not possible so a process is undertaken which parallels the natural oxidation that occurs in the marine atmosphere and produces MSM that is chemically identical to that found in nature.

Click here for a detailed explanation of how MSM is manufactured.

How pure is MISMO MSM?

Every batch of our MSM is rigourously tested by an independent laboratory to ensure the highest quality, minimum 99.99% pure MSM.

    How much MISMO MSM should I be taking?

    An average dose is between 2 to 6 grams daily. Most people take a teaspoon (approx. 4 grams) daily. If more relief is needed, increase the dose slowly. Can be taken in water or juice after breakfast, although there are no rules as to when you should take MSM.

    A word of caution ... some people find if they take MSM late in the day, after 4 or 5pm, they do not sleep as well, as it energises them. This is not a general occurrence but worth mentioning.

    WARNINGS: If taking Warfarin or strong blood thinners, do not take MSM without your doctor's approval. Not to be taken by children without a health professional's advice.  MSM can also interfere with the accuracy of the blood test for liver enzymes by sometimes producing false positive results. It is recommended you cease taking MSM at least 4 days before these blood tests. You can resume after the test.

    Is MISMO MSM listed with the TGA (Therapeutic Goods Administration)?

    Yes, click here to view the TGA listing for MISMO MSM


      Customer Reviews

      Based on 152 reviews
      Barbara Ulanowski
      Cell Soother

      Leaves skin feeling soft and soothes blemishes

      Cathryn Heap

      Have been using the msm for a couple of years now and have been happy with the product. Will continue to use in future.

      Roger Watts


      Martin Bruekers

      Expedient and good product.

      msm everyday

      Take a spoonful everyday with my morning juice.
      Makes a difference to the aches and pains of ageing.