we have been using MSM on and off for several years, originally purchasing it from overseas. We are very happy with Mismo brand price and prompt service. We began taking it again for post amputation phantom pain, and find it helpful. We are in our mid and late 70s; and find our snowy hair is getting darker...I wonder how far that will go! My fingernails were quite bendy and are now quite hard and have lost most of the ridges they were developing. MSM helps greatly with our aches and pains, and helps our energy levels; it gives us a clearer head and helps us feel brighter and keeps our digestive system moving. We believe it is helping husband's Crohns, and have read it is supposed to help, although we are not expecting a cure...it is still new days for that, and he has the specialist's support. All in all we wonder why we ever stopped taking MSM, and have vowed not to stop again. At our age we need all the help we can get.