If you’re serious about softening lines and keeping skin bouncy as you get older, Matrixyl Synthe’6® is one of the ingredients worth knowing. It’s a next-generation peptide (palmitoyl tripeptide-38) designed to stimulate the skin’s own building processes, so you’re not just hydrating the surface — you’re helping the deeper layers look and act more youthful. Read the blog.
At MISMO we use Matrixyl Synthe’6 in formulas like our Rejuvenating Serum because it’s a proven, high-performance active — even though it’s more expensive than many standard ingredients. We only include ingredients that earn their spot.
Quick refresher: what are peptides?
Peptides are short chains of amino acids. Your skin uses amino acids to build bigger, more complex proteins — like collagen and elastin — that keep skin firm, smooth and resilient. When you apply certain peptides topically, they can “signal” the skin to step up this repair work. Matrixyl Synthe’6 is one of those signalling peptides.
What makes Matrixyl Synthe’6 different?
Older peptide blends mostly focused on collagen. Matrixyl Synthe’6 was developed to go broader — it targets six major components of the dermal matrix (think collagen, hyaluronic acid and key proteins that keep the skin structure organised). That’s why you’ll sometimes see it described as helping to “rebuild from the inside.” The result people notice: skin looks smoother, forehead/crow’s-feet lines look softer, and the surface feels more even.
What kind of results can it support?
When used consistently inside a well-formulated serum or moisturiser:
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Softer expression lines — especially on the forehead and around the eyes
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Better firmness and bounce because more structural components are being made
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Smoother skin texture so makeup sits better
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Support for long-term anti-ageing routines — it works well alongside hyaluronic acid, MSM and vitamins A/C/E (all of which we use at MISMO)
Where you’ll find it at MISMO
You’ll find Matrixyl Synthe’6 in our hero anti-ageing formula, Rejuvenating Serum — a lightweight, fast-absorbing serum that also contains 50% hyaluronic acid, MSM and organic aloe to hydrate and calm at the same time. It’s designed for people who want visible results without irritation.
If you prefer a ready-made routine, you can build it into your regimen with our anti-ageing skincare options or start small with trial sizes.
How to add it to your routine
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Cleanse with a gentle cleanser (no stripping).
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Apply your Matrixyl Synthe’6 serum to slightly damp skin — that’s where Rejuvenating Serum fits.
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Seal with moisturiser — try Nourishing Cream or your usual MISMO moisturiser.
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SPF in the day — peptides help, but sun protection keeps the collagen you’re building.
Use morning and/or night — consistency matters more than time of day.
Who is it best for?
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Skin showing early lines or crow’s feet
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40+ skin wanting more support for firmness
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Dry or dehydrated skin that also wants anti-ageing
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Anyone who prefers evidence-based actives over “filler” ingredients
It’s also a good option if you’re sensitive to stronger retinoids but still want something that talks to the skin’s repair pathways.
Why we chose to use it
Not many brands use Matrixyl Synthe’6 because it’s a premium peptide. We do — because MISMO has always been about formulas that actually perform, not just look good on the label. If an ingredient helps our customers see real improvements in lines, texture and hydration, we’ll make room for it.
Keep learning
If you like understanding what’s inside your skincare, browse our Skincare Blogs - we break down ingredients, routines and ageing concerns in plain English.
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