The Benefits of MSM in Skincare: What Science Says

The Benefits of MSM in Skincare: What Science Says

When it comes to skincare, there’s always a surge in interest around ingredients that promise to deliver multiple benefits for skin health. One such ingredient is MSM (methylsulfonylmethane), a naturally occurring sulfur compound known for its anti-inflammatory, antioxidant, and collagen-boosting properties. With studies increasingly pointing to its effectiveness, MSM has become a favorite in many skincare products. In this blog post, we’ll explore the science behind MSM and how it benefits the skin.

What is MSM?

MSM is an organic sulfur compound found naturally in plants, animals, and humans. It plays an essential role in the body, particularly in the synthesis of collagen and keratin—two key proteins that keep our skin, hair, and nails strong and healthy. MSM is often used as a supplement for its anti-inflammatory properties and is increasingly incorporated into skincare products for its ability to promote healthier skin.

1. Reduces Inflammation and Redness

One of MSM’s most well-known benefits is its ability to reduce inflammation. Inflammation plays a central role in many skin conditions, including acne, rosacea, and eczema. A study published in the Journal of Drugs in Dermatology found that MSM applied topically helped reduce redness and inflammation in patients with rosacea, a condition that causes persistent facial redness. This is significant because persistent inflammation can lead to long-term damage and aging in the skin, but MSM’s ability to calm inflammation can mitigate this.

2. Supports Collagen Production

Collagen is the protein responsible for keeping skin firm and youthful. As we age, our natural collagen production decreases, leading to wrinkles and sagging skin. MSM can help support collagen synthesis, which is crucial for maintaining skin elasticity. A 2015 study in the National Institutes of Health found that MSM supplementation improved the appearance of fine lines and wrinkles by enhancing collagen production. This makes MSM an excellent ingredient for anyone looking to keep their skin plump and youthful.

3. Improves Skin Hydration

Dry skin is a common issue for many people, especially in colder months. MSM has been shown to improve skin hydration by enhancing the skin's ability to retain moisture. A study published in the Journal of Cosmetic Dermatology found that topical application of MSM resulted in increased skin hydration and moisture retention, making it a great ingredient for anyone looking to achieve a more dewy and nourished complexion.

4. Reduces Hyperpigmentation and Dark Spots

MSM’s role in promoting healthy skin doesn’t stop at hydration and collagen production—it may also help reduce hyperpigmentation. Some studies suggest that MSM can lighten dark spots, sun damage, and hyperpigmentation, especially when combined with other brightening ingredients like vitamin C. A study from Antioxidants journal showed that MSM has a depigmenting effect on skin and can help even out skin tone.

5. Heals and Repairs Skin Damage

MSM's natural healing properties also make it effective in promoting the repair of damaged skin. For individuals with acne scars or wounds, MSM can speed up the healing process and reduce the appearance of scars. In fact, studies suggest that MSM may encourage the repair of skin tissues and promote faster healing by stimulating the production of key molecules that support skin repair. Research in the Journal of Clinical and Aesthetic Dermatology revealed that MSM supplementation accelerated wound healing and improved the appearance of post-acne scars.

6. Antioxidant Protection Against Environmental Stress

Free radicals, generated by UV exposure, pollution, and environmental toxins, contribute to premature aging and skin damage. MSM acts as an antioxidant, helping to neutralize these free radicals. Research published in the International Journal of Molecular Sciences found that MSM can help protect skin cells from oxidative stress, thus reducing the impact of environmental stressors on the skin. This makes MSM a valuable ingredient in anti-aging skincare formulations.

How to Use MSM in Your Skincare Routine

MSM can be found in various skincare products, including creams, serums, masks, and oils. For optimal results, choose a product that combines MSM with other beneficial ingredients, such as vitamin C for brightening or hyaluronic acid for hydration.

  • Topical Application: Look for MSM-enriched moisturizers or serums that can be applied directly to the skin after cleansing.
  • Supplements: You can also take MSM supplements to support skin health from within. However, always consult a healthcare professional before starting any supplementation regimen.

The evidence supporting MSM in skincare is mounting, with studies highlighting its ability to reduce inflammation, support collagen production, improve hydration, and promote skin healing. Whether you’re struggling with redness, acne scars, or fine lines, MSM is a versatile and effective ingredient to incorporate into your skincare routine. As always, make sure to patch-test any new products and consult with a dermatologist if you have concerns.

By harnessing the power of MSM, you can help your skin maintain its natural radiance, strength, and youthful appearance—naturally.


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MISMO MSM - 440g / Ultra-Pure Distilled - Pain Relief
MISMO MSM - Pain Relief
MISMO MSM - Capsules / Ultra-Pure Distilled - Pain Relief
MSM capsules pain relief
MISMO MSM - 440g / Pure Crystalline - Pain Relief
MISMO MSM - 850g Ultra-Pure Distilled - Pain Relief
MISMO MSM - 850g/ Pure Crystalline - Pain Relief
MISMO MSM - 2kg Ultra-Pure Distilled - Pain Relief
MISMO MSM - 2kg / Pure Crystalline - Pain Relief
MISMO MSM - Capsules/ Ultra-Pure Distilled - Pain Relief
MISMO MSM - Capsules / Ultra-Pure Distilled - Pain Relief

MISMO MSM

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MSM (Methyl Sulphonyl Methane or Dimethyl Sulfone) is an organic sulfur compound found in all living organisms. It is the purest and most bio-available form of sulfur, a crucial mineral for life and cellular regeneration. MSM has long been used as a supplement to support joint health, improve flexibility and mobility, and enhance the strength of hair and nails.

In addition to its joint benefits, MSM is commonly recommended for skin health, helping with conditions like psoriasis and leaky gut syndrome. It’s also supportive for those dealing with mild arthritis and osteoporosis due to its anti-inflammatory properties.

MSM is recommended for those who:

  • Experience joint pain, stiffness, or swelling
  • Want to improve skin conditions like psoriasis
  • Are looking for strong hair, nails, and healthy skin
  • Seek relief from digestive issues like leaky gut syndrome
  • Want to support bone health and manage arthritis

What is the science of MSM?

Sulphur is integral to the production of collagen and elastin, and MSM is a source of organic Sulphur. Collagen is the principal structural protein holding the skin together and is largely responsible for the skin’s mechanical properties.  Approximately half of the body's sulphur content is found in the skin, muscles, cartilage and bones.

Click here for more information on The Science of MSM

Why do we need to supplement with MSM?

Natural MSM is largely destroyed when our food is processed and can be lost entirely when foods and ingredients are stored for a long period of time. MSM bonds with moisture, so any food which undergoes any sort of dehydration will lack its natural MSM.

For these reasons, and because MSM is so critical for almost every athletic function in active bodies, it is important to consistently supplement with a quality MSM nutritional supplement.

How will MSM benefit me?

MSM for Skin, Hair, and Nails

MSM helps protect collagen from degrading enzymes, reducing fine lines and wrinkles by boosting collagen and elastin production. It also increases the body’s natural production of glutathione, a key antioxidant, which supports the immune system, reduces pigmentation, and prevents cellular damage. MSM acts as an anti-inflammatory, reducing cytokine production (inflammatory compounds) and maintains skin cell membrane flexibility, allowing for better nutrient exchange, keeping skin clear and healthy.

MSM for Joint Health

MSM’s powerful anti-inflammatory properties make it a natural option for reducing pain and inflammation associated with mild arthritis and osteoarthritis. It helps support joint mobility and flexibility by delivering essential sulfur to cartilage and connective tissue, making it valuable for joint health.

MSM for Exercise Recovery

MSM is important for those with active lifestyles, delivering sulfur and methyl nutrients needed for healthy cells in muscles and connective tissues. It supports flexible cell structures, reduces inflammation in muscle tissue, and helps alleviate muscle soreness and joint pain caused by exercise-related inflammation. This makes it especially valued by bodybuilders and athletes for faster recovery and enhanced performance.

Should I buy capsules or powder?

The main difference between MSM capsules and powder comes down to convenience and cost. MSM powder is more economical, as you get more product for the price, making it a great option for daily use at home. However, MSM capsules are more convenient for traveling and ideal for those who don’t enjoy the natural bitter taste of MSM powder, offering a tasteless, easy-to-take alternative.

Where is MSM found and how is it manufactured?

MSM is found in the fluid and tissue of all living organisms. It is present in a variety of foods including raw vegetables, eggs, milk and fish, but is lost through cooking and food processing. One of the richest natural supplies is pine trees and cabbage.

Although MSM is abundant in nature, even the richest natural sources only provide MSM in the level of several parts per million. Commercial extraction of MSM from trees is not possible so a process is undertaken which parallels the natural oxidation that occurs in the marine atmosphere and produces MSM that is a chemical compound identical to that found in nature.

Click here for a detailed explanation of how MSM is manufactured.

What is the difference between Distilled Ultra-Pure MSM and Pure-Crystalline MSM?

With the distilled product, the MSM solution is heated up to a point where the MSM is released as a vapour and the pure crystals are formed and harvested as the vapour cools on the inside surface of a distillation column.  The heating-up of the MSM solution and the subsequent cooling and harvesting process requires a lot more energy, and hence the reason why the price is marginally higher.

With the crystalline product, the MSM solution is spun at super-high speed in a centrifuge and the MSM crystals are formed on the walls of the centrifuge.  The solution has undergone a reverse-osmosis filtration process before the crystallisation process begins and is highly-pure.  This being said, the more costly distillation process is regarded as the gold-standard.

How pure is MISMO MSM?

Every batch of our MSM is rigourously tested by an independent laboratory to ensure the highest possible quality with no additives or anti-caking agents. MSM is gluten free and vegan / vegetarian. Packaged in Australia from imported ingredients.

    How much MISMO MSM should I be taking?

    Start with 1/4 - 1/2 tsp per day (or 1-2 capsules). This is to prevent potential detox side effects (headache or nausea). These are easily avoided with a low start dosage and adequate hydration. 

    After one week, start slowly increasing to the average dose of 2 to 6 grams daily (or 5-6 capsules). Most people take a teaspoon (approx. 4 grams) daily. If more relief is needed, increase the dose slowly. Can be taken in water or juice after breakfast, although there are no rules as to when you should take MSM.

    It is recommended to take MSM in the morning, as it can give a boost of energy. Side effects when starting out with MSM can be nausea and/or headaches. This is not uncommon and is linked to the detoxifying benefits of MSM. We recommend lowering your dose if experiencing these symptoms and gradually increasing with time.

    WARNINGS: If taking strong blood thinners, do not take MSM without your doctor's approval. Not to be taken by children without a health professional's advice.  MSM can also interfere with the accuracy of the blood test for liver enzymes by sometimes producing false positive results. It is recommended you cease taking MSM at least 4 days before these blood tests. You can resume after the test.

    Is MISMO MSM listed with the TGA (Therapeutic Goods Administration)?

    Yes, click here to view the TGA listing for MISMO MSM

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