Can Collagen Reduce Joint Pain and Arthritis?

Can Collagen Reduce Joint Pain and Arthritis?

Collagen is widely known for its benefits to skin health, but it plays an equally important role in maintaining joint function and reducing symptoms of joint pain and arthritis. As the most abundant protein in the body, collagen is a key component of cartilage, the tissue that cushions joints. Over time, as collagen levels decrease with age, cartilage can deteriorate, leading to joint pain and conditions such as osteoarthritis.

Many people turn to collagen supplements with the hope of easing joint discomfort and improving mobility. But does collagen really help with joint pain and arthritis? Let's explore the science behind collagen’s impact on joint health and review studies that support its role in reducing joint pain and inflammation.

Understanding Joint Health and Arthritis

Arthritis is a broad term for conditions that cause joint pain and inflammation, with osteoarthritis being the most common form. Osteoarthritis occurs when the cartilage between joints wears down over time, leading to pain, stiffness, and reduced mobility. As cartilage deteriorates, bones may rub against each other, causing discomfort and swelling.

Cartilage is made up of collagen, specifically Type II collagen, which gives it its structure and cushioning properties. When collagen production declines or cartilage is damaged, joint pain and stiffness can worsen. Therefore, many believe that supplementing with collagen can help rebuild cartilage, reduce inflammation, and ease arthritis symptoms.

How Collagen May Help Reduce Joint Pain

Collagen supplements, particularly in hydrolyzed form (collagen peptides), are broken down into smaller amino acids that are easily absorbed by the body. These amino acids are then used by the body to repair and rebuild cartilage and connective tissue in the joints.

Research suggests that collagen supplements may help reduce joint pain and improve joint function by:

  • Supporting Cartilage Repair: Collagen supplements provide the body with the amino acids needed to repair damaged cartilage, potentially slowing the progression of joint deterioration.
  • Reducing Inflammation: Collagen contains specific peptides that may help reduce inflammation, a key driver of arthritis-related pain.
  • Promoting Joint Lubrication: Collagen may help improve joint lubrication by supporting synovial fluid production, which keeps joints cushioned and reduces friction during movement.

What Does the Research Say?

Several studies have explored the effects of collagen supplementation on joint pain and arthritis, and the results are promising:

  1. Reduction in Osteoarthritis Symptoms A study published in The International Journal of Medical Sciences found that patients with osteoarthritis who took collagen hydrolysate for 13 weeks experienced significant reductions in joint pain and improved joint function compared to those who took a placebo (Lugo et al., 2016). The study concluded that collagen hydrolysate may provide relief for those with osteoarthritis, particularly in the knee and hip joints.

  2. Improved Joint Mobility in Athletes Another study published in the journal Applied Physiology, Nutrition, and Metabolism showed that athletes who supplemented with collagen peptides experienced less joint pain during physical activity compared to those who took a placebo (Clark et al., 2008). The researchers noted that collagen supplementation could be beneficial for maintaining joint health, especially for individuals who put stress on their joints through repetitive movement or high-impact activities.

  3. Cartilage Preservation In a study published in Current Medical Research and Opinion, researchers found that patients with osteoarthritis who took collagen hydrolysate showed improvements in cartilage preservation and reduced symptoms of joint pain over time (Moskowitz, 2000). The study suggested that collagen may help slow the breakdown of cartilage in people with osteoarthritis, potentially delaying the need for more invasive treatments like joint replacement surgery.

Types of Collagen for Joint Health

When it comes to joint health, not all collagen types are equally effective. The two most relevant types for reducing joint pain and arthritis are:

  • Type II Collagen: This type of collagen is the primary component of cartilage and is especially important for maintaining joint structure and cushioning. Type II collagen is often derived from chicken sternum in supplements and is thought to be most effective for treating arthritis and cartilage-related issues.

  • Hydrolyzed Collagen (Collagen Peptides): Hydrolyzed collagen is broken down into smaller, more easily absorbed particles that can circulate in the bloodstream and reach the joints. Studies suggest that hydrolyzed collagen, which includes a mix of Type I and II, may support joint health by reducing pain and inflammation, and promoting cartilage repair.

How Long Does It Take to See Results?

As with any supplement, the effects of collagen on joint pain may take time to become noticeable. Most studies on collagen for joint health suggest that it can take anywhere from 8 to 24 weeks of consistent use to see significant improvements in joint function and reductions in pain. The timeline for results may vary depending on the severity of the arthritis and individual response to the supplement.

Other Ingredients to Look for in Joint Supplements

For those seeking additional joint support, many collagen supplements are formulated with complementary ingredients that enhance their effectiveness. Look for products that include:

  • Glucosamine and Chondroitin: These compounds are naturally found in cartilage and may help slow cartilage breakdown and reduce pain and inflammation.
  • Hyaluronic Acid: Known for its ability to retain moisture, hyaluronic acid helps lubricate joints, reducing friction and improving joint mobility.
  • Vitamin C: This vitamin is essential for collagen synthesis in the body and can boost the effectiveness of collagen supplements for joint health.

Collagen Supplements vs. Other Joint Treatments

While collagen supplements show promise in reducing joint pain and arthritis symptoms, they are not a substitute for other medical treatments or interventions. For those with severe arthritis, a combination of treatments, including physical therapy, anti-inflammatory medications, and lifestyle changes (such as weight management and low-impact exercise), may be necessary to manage symptoms effectively.

Conclusion: Can Collagen Help with Joint Pain and Arthritis?

The research supports the idea that collagen supplements can help reduce joint pain and improve mobility, particularly for individuals with osteoarthritis. By providing the body with the building blocks it needs to repair cartilage, collagen supplements may offer a non-invasive option for managing joint discomfort and slowing the progression of arthritis.

For those seeking natural support for joint health, collagen supplements—especially those containing hydrolyzed collagen or Type II collagen—may provide significant benefits. However, as with any supplement, it’s important to maintain realistic expectations, use the product consistently, and combine it with other joint-friendly practices for optimal results.


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MISMO MSM - 440g / Ultra-Pure Distilled - Pain Relief
MISMO MSM - Pain Relief
MISMO MSM - Capsules / Ultra-Pure Distilled - Pain Relief
MSM capsules pain relief
MISMO MSM - 440g / Pure Crystalline - Pain Relief
MISMO MSM - 850g Ultra-Pure Distilled - Pain Relief
MISMO MSM - 850g/ Pure Crystalline - Pain Relief
MISMO MSM - 2kg Ultra-Pure Distilled - Pain Relief
MISMO MSM - 2kg / Pure Crystalline - Pain Relief
MISMO MSM - Capsules/ Ultra-Pure Distilled - Pain Relief
MISMO MSM - Capsules / Ultra-Pure Distilled - Pain Relief

MISMO MSM

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MSM (Methyl Sulphonyl Methane or Dimethyl Sulfone) is an organic sulfur compound found in all living organisms. It is the purest and most bio-available form of sulfur, a crucial mineral for life and cellular regeneration. MSM has long been used as a supplement to support joint health, improve flexibility and mobility, and enhance the strength of hair and nails.

In addition to its joint benefits, MSM is commonly recommended for skin health, helping with conditions like psoriasis and leaky gut syndrome. It’s also supportive for those dealing with mild arthritis and osteoporosis due to its anti-inflammatory properties.

MSM is recommended for those who:

  • Experience joint pain, stiffness, or swelling
  • Want to improve skin conditions like psoriasis
  • Are looking for strong hair, nails, and healthy skin
  • Seek relief from digestive issues like leaky gut syndrome
  • Want to support bone health and manage arthritis

What is the science of MSM?

Sulphur is integral to the production of collagen and elastin, and MSM is a source of organic Sulphur. Collagen is the principal structural protein holding the skin together and is largely responsible for the skin’s mechanical properties.  Approximately half of the body's sulphur content is found in the skin, muscles, cartilage and bones.

Click here for more information on The Science of MSM

Why do we need to supplement with MSM?

Natural MSM is largely destroyed when our food is processed and can be lost entirely when foods and ingredients are stored for a long period of time. MSM bonds with moisture, so any food which undergoes any sort of dehydration will lack its natural MSM.

For these reasons, and because MSM is so critical for almost every athletic function in active bodies, it is important to consistently supplement with a quality MSM nutritional supplement.

How will MSM benefit me?

MSM for Skin, Hair, and Nails

MSM helps protect collagen from degrading enzymes, reducing fine lines and wrinkles by boosting collagen and elastin production. It also increases the body’s natural production of glutathione, a key antioxidant, which supports the immune system, reduces pigmentation, and prevents cellular damage. MSM acts as an anti-inflammatory, reducing cytokine production (inflammatory compounds) and maintains skin cell membrane flexibility, allowing for better nutrient exchange, keeping skin clear and healthy.

MSM for Joint Health

MSM’s powerful anti-inflammatory properties make it a natural option for reducing pain and inflammation associated with mild arthritis and osteoarthritis. It helps support joint mobility and flexibility by delivering essential sulfur to cartilage and connective tissue, making it valuable for joint health.

MSM for Exercise Recovery

MSM is important for those with active lifestyles, delivering sulfur and methyl nutrients needed for healthy cells in muscles and connective tissues. It supports flexible cell structures, reduces inflammation in muscle tissue, and helps alleviate muscle soreness and joint pain caused by exercise-related inflammation. This makes it especially valued by bodybuilders and athletes for faster recovery and enhanced performance.

Should I buy capsules or powder?

The main difference between MSM capsules and powder comes down to convenience and cost. MSM powder is more economical, as you get more product for the price, making it a great option for daily use at home. However, MSM capsules are more convenient for traveling and ideal for those who don’t enjoy the natural taste of MSM powder, offering a tasteless, easy-to-take alternative.

Where is MSM found and how is it manufactured?

MSM is found in the fluid and tissue of all living organisms. It is present in a variety of foods including raw vegetables, eggs, milk and fish, but is lost through cooking and food processing. One of the richest natural supplies is pine trees and cabbage.

Although MSM is abundant in nature, even the richest natural sources only provide MSM in the level of several parts per million. Commercial extraction of MSM from trees is not possible so a process is undertaken which parallels the natural oxidation that occurs in the marine atmosphere and produces MSM that is a chemical compound identical to that found in nature.

Click here for a detailed explanation of how MSM is manufactured.

What is the difference between Distilled Ultra-Pure MSM and Pure-Crystalline MSM?

With the distilled product, the MSM solution is heated up to a point where the MSM is released as a vapour and the pure crystals are formed and harvested as the vapour cools on the inside surface of a distillation column.  The heating-up of the MSM solution and the subsequent cooling and harvesting process requires a lot more energy, and hence the reason why the price is a bit higher.

With the crystalline product, the MSM solution is "spun" at super-high speed in a centrifuge and the MSM crystals are formed on the walls of the centrifuge.  And although the MSM solution is highly-pure before the crystallisation process begins (having undergone a reverse-osmosis filtration process), there is a remote possibility that if there are any trace impurities in the solution they can become encapsulated in the crystalline structure.

How pure is MISMO MSM?

Every batch of our MSM is rigourously tested by an independent laboratory to ensure the highest possible quality with no additives or anti-caking agents. MSM is gluten free and vegan / vegetarian. Packaged in Australia from imported ingredients.

    How much MISMO MSM should I be taking?

    Start with 1/4 - 1/2 tsp per day (or 1-2 capsules). This is to prevent potential detox side effects (headache or nausea). These are easily avoided with a low start dosage and adequate hydration. 

    After one week, start slowly increasing to the average dose of 2 to 6 grams daily (or 5-6 capsules). Most people take a teaspoon (approx. 4 grams) daily. If more relief is needed, increase the dose slowly. Can be taken in water or juice after breakfast, although there are no rules as to when you should take MSM.

    It is recommended to take MSM in the morning, as it can give a boost of energy. Side effects when starting out with MSM can be nausea and/or headaches. This is not uncommon and is linked to the detoxifying benefits of MSM. We recommend lowering your dose if experiencing these symptoms and gradually increasing with time.

    WARNINGS: If taking strong blood thinners, do not take MSM without your doctor's approval. Not to be taken by children without a health professional's advice.  MSM can also interfere with the accuracy of the blood test for liver enzymes by sometimes producing false positive results. It is recommended you cease taking MSM at least 4 days before these blood tests. You can resume after the test.

    Is MISMO MSM listed with the TGA (Therapeutic Goods Administration)?

    Yes, click here to view the TGA listing for MISMO MSM

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