The Role of Collagen in Cartilage and Bone Health

The Role of Collagen in Cartilage and Bone Health

Collagen is often praised for its benefits to skin and hair, but its role in maintaining the health of cartilage and bones is equally important. As the most abundant protein in the body, collagen is crucial for the structural integrity of various tissues, including cartilage and bones. Without adequate collagen, our joints would lack the cushioning they need, and bones would lose their strength and resilience, leading to conditions like osteoarthritis and osteoporosis.

Keep reading to learn about the role of collagen in cartilage and bone health, explore how collagen supplementation can help, and review the research backing its use for musculoskeletal health.

What is Collagen?

Collagen is a fibrous protein that acts as a building block for skin, tendons, cartilage, bones, and other connective tissues. There are many types of collagen, but Types I and II are most relevant to cartilage and bone health:

  • Type I Collagen: This is the most abundant type of collagen and is primarily found in bones, tendons, and ligaments. It gives bones their tensile strength and helps maintain bone density.
  • Type II Collagen: Type II collagen is the primary component of cartilage, the tissue that cushions joints and allows smooth, pain-free movement.

As we age, the body's natural production of collagen declines, leading to a loss of structural integrity in both cartilage and bones. This decline can contribute to joint pain, reduced mobility, and a higher risk of bone fractures.

Collagen's Role in Cartilage Health

Cartilage is a flexible, rubbery tissue that covers the ends of bones in joints, allowing for smooth movement and shock absorption. Type II collagen is a major component of cartilage and provides the tissue with its tensile strength and elasticity. Collagen fibers form a scaffold within the cartilage matrix, maintaining the shape and integrity of the tissue.

When collagen production decreases, the cartilage starts to break down, which can lead to conditions like osteoarthritis. In osteoarthritis, the loss of cartilage causes bones to rub together, resulting in pain, inflammation, and joint stiffness. Supplementing with collagen may help protect cartilage from further deterioration and reduce the symptoms associated with joint issues.

Research supports the idea that collagen supplements, particularly hydrolyzed collagen or collagen peptides, can play a role in maintaining and even rebuilding cartilage. A 2016 study published in Nutrition Journal found that collagen supplementation improved cartilage health and reduced joint pain in individuals with osteoarthritis (König et al., 2016).

Collagen's Role in Bone Health

Bones are made up of a combination of minerals, primarily calcium and phosphorus, as well as a collagen matrix that gives bones their structure and flexibility. Type I collagen forms a dense network in bone tissue, providing a scaffold on which minerals can be deposited. This matrix is essential for maintaining bone density and preventing fractures.

As we age, the body produces less collagen, and bones can become more brittle and prone to fractures. This process is accelerated in individuals with osteoporosis, a condition characterized by low bone mass and deterioration of bone tissue. Without enough collagen, bones lose their resilience and strength, making them more vulnerable to breaks and fractures.

Studies suggest that collagen supplementation may help improve bone density and reduce the risk of fractures. A 2018 study published in the Journal of Clinical Medicine found that postmenopausal women who took collagen supplements showed improvements in bone mineral density and had lower levels of bone degradation markers compared to those who did not take collagen (König et al., 2018).

How Collagen Supplements Benefit Cartilage and Bones

Collagen supplements, particularly hydrolyzed collagen (also known as collagen peptides), are broken down into smaller amino acids that the body can readily absorb and use. When taken as a supplement, these amino acids help stimulate the body’s natural collagen production, supporting the repair and maintenance of cartilage and bone tissue.

Here are the key ways collagen supplements benefit cartilage and bone health:

  1. Cartilage Repair: Collagen peptides provide the building blocks for cartilage regeneration, helping to maintain cartilage thickness and reducing joint pain and stiffness.

  2. Bone Density Improvement: Collagen stimulates the production of osteoblasts, the cells responsible for bone formation. This process helps to maintain bone density and prevent bone loss, which is especially important in aging populations.

  3. Joint Lubrication: Collagen also supports the production of synovial fluid, which lubricates the joints and reduces friction during movement, further protecting cartilage from wear and tear.

  4. Anti-Inflammatory Effects: Some studies suggest that collagen supplements may help reduce inflammation in joints and bones, which is beneficial for conditions like osteoarthritis and rheumatoid arthritis. Inflammatory processes are often responsible for pain and tissue damage in these conditions, and collagen can potentially help mitigate this.

Scientific Evidence Supporting Collagen for Joint and Bone Health

Several studies support the use of collagen supplements for improving both cartilage and bone health:

  1. Cartilage Health and Joint Pain Relief A randomized controlled trial published in Current Medical Research and Opinion found that individuals with osteoarthritis who took collagen hydrolysate for 24 weeks experienced significant improvements in joint pain and mobility compared to those who took a placebo (Moskowitz, 2000). The study suggests that collagen may help protect and repair cartilage in individuals with joint degeneration.

  2. Bone Density in Postmenopausal Women A study published in the Journal of Clinical Medicine found that postmenopausal women who took collagen peptides showed a significant increase in bone mineral density after 12 months of supplementation. The women in the study also showed a reduction in bone degradation markers, suggesting that collagen may slow down the rate of bone loss in aging individuals (König et al., 2018).

  3. Osteoporosis and Fracture Prevention Another study published in Osteoporosis International found that hydrolyzed collagen supplementation improved bone mineral density and reduced the risk of fractures in women with osteoporosis (Asserin et al., 2015). The researchers concluded that collagen could play an important role in maintaining bone health and preventing bone loss in postmenopausal women.

Best Collagen Supplements for Cartilage and Bone Health

When choosing a collagen supplement for joint and bone health, consider the following factors:

  • Hydrolyzed Collagen (Collagen Peptides): Hydrolyzed collagen is broken down into smaller peptides, which are more easily absorbed by the body and can be used to support cartilage and bone health.

  • Type II Collagen: For cartilage health, look for supplements that contain Type II collagen, which is specifically beneficial for joint health.

  • Complementary Ingredients: Some collagen supplements are formulated with additional ingredients like glucosamine, chondroitin, or calcium to further support joint and bone health.

Collagen’s Essential Role in Cartilage and Bone Health

Collagen plays a vital role in maintaining the structural integrity of cartilage and bones. As we age and collagen production declines, the risk of joint pain, osteoarthritis, and osteoporosis increases. Collagen supplements, particularly hydrolyzed collagen, offer a promising way to support cartilage repair, improve bone density, and reduce inflammation in the joints.

For those looking to protect their joints and bones, collagen supplements may provide significant benefits, especially when combined with other joint-friendly practices such as weight-bearing exercise, a balanced diet rich in calcium and vitamin D, and avoiding excessive strain on the joints.


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MISMO MSM - 440g / Ultra-Pure Distilled - Pain Relief
MISMO MSM - Pain Relief
MISMO MSM - Capsules / Ultra-Pure Distilled - Pain Relief
MSM capsules pain relief
MISMO MSM - 440g / Pure Crystalline - Pain Relief
MISMO MSM - 850g Ultra-Pure Distilled - Pain Relief
MISMO MSM - 850g/ Pure Crystalline - Pain Relief
MISMO MSM - 2kg Ultra-Pure Distilled - Pain Relief
MISMO MSM - 2kg / Pure Crystalline - Pain Relief
MISMO MSM - Capsules/ Ultra-Pure Distilled - Pain Relief
MISMO MSM - Capsules / Ultra-Pure Distilled - Pain Relief

MISMO MSM

Regular price$38.00 AUD
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MSM (Methyl Sulphonyl Methane or Dimethyl Sulfone) is an organic sulfur compound found in all living organisms. It is the purest and most bio-available form of sulfur, a crucial mineral for life and cellular regeneration. MSM has long been used as a supplement to support joint health, improve flexibility and mobility, and enhance the strength of hair and nails.

In addition to its joint benefits, MSM is commonly recommended for skin health, helping with conditions like psoriasis and leaky gut syndrome. It’s also supportive for those dealing with mild arthritis and osteoporosis due to its anti-inflammatory properties.

MSM is recommended for those who:

  • Experience joint pain, stiffness, or swelling
  • Want to improve skin conditions like psoriasis
  • Are looking for strong hair, nails, and healthy skin
  • Seek relief from digestive issues like leaky gut syndrome
  • Want to support bone health and manage arthritis

What is the science of MSM?

Sulphur is integral to the production of collagen and elastin, and MSM is a source of organic Sulphur. Collagen is the principal structural protein holding the skin together and is largely responsible for the skin’s mechanical properties.  Approximately half of the body's sulphur content is found in the skin, muscles, cartilage and bones.

Click here for more information on The Science of MSM

Why do we need to supplement with MSM?

Natural MSM is largely destroyed when our food is processed and can be lost entirely when foods and ingredients are stored for a long period of time. MSM bonds with moisture, so any food which undergoes any sort of dehydration will lack its natural MSM.

For these reasons, and because MSM is so critical for almost every athletic function in active bodies, it is important to consistently supplement with a quality MSM nutritional supplement.

How will MSM benefit me?

MSM for Skin, Hair, and Nails

MSM helps protect collagen from degrading enzymes, reducing fine lines and wrinkles by boosting collagen and elastin production. It also increases the body’s natural production of glutathione, a key antioxidant, which supports the immune system, reduces pigmentation, and prevents cellular damage. MSM acts as an anti-inflammatory, reducing cytokine production (inflammatory compounds) and maintains skin cell membrane flexibility, allowing for better nutrient exchange, keeping skin clear and healthy.

MSM for Joint Health

MSM’s powerful anti-inflammatory properties make it a natural option for reducing pain and inflammation associated with mild arthritis and osteoarthritis. It helps support joint mobility and flexibility by delivering essential sulfur to cartilage and connective tissue, making it valuable for joint health.

MSM for Exercise Recovery

MSM is important for those with active lifestyles, delivering sulfur and methyl nutrients needed for healthy cells in muscles and connective tissues. It supports flexible cell structures, reduces inflammation in muscle tissue, and helps alleviate muscle soreness and joint pain caused by exercise-related inflammation. This makes it especially valued by bodybuilders and athletes for faster recovery and enhanced performance.

Should I buy capsules or powder?

The main difference between MSM capsules and powder comes down to convenience and cost. MSM powder is more economical, as you get more product for the price, making it a great option for daily use at home. However, MSM capsules are more convenient for traveling and ideal for those who don’t enjoy the natural bitter taste of MSM powder, offering a tasteless, easy-to-take alternative.

Where is MSM found and how is it manufactured?

MSM is found in the fluid and tissue of all living organisms. It is present in a variety of foods including raw vegetables, eggs, milk and fish, but is lost through cooking and food processing. One of the richest natural supplies is pine trees and cabbage.

Although MSM is abundant in nature, even the richest natural sources only provide MSM in the level of several parts per million. Commercial extraction of MSM from trees is not possible so a process is undertaken which parallels the natural oxidation that occurs in the marine atmosphere and produces MSM that is a chemical compound identical to that found in nature.

Click here for a detailed explanation of how MSM is manufactured.

What is the difference between Distilled Ultra-Pure MSM and Pure-Crystalline MSM?

With the distilled product, the MSM solution is heated up to a point where the MSM is released as a vapour and the pure crystals are formed and harvested as the vapour cools on the inside surface of a distillation column.  The heating-up of the MSM solution and the subsequent cooling and harvesting process requires a lot more energy, and hence the reason why the price is marginally higher.

With the crystalline product, the MSM solution is spun at super-high speed in a centrifuge and the MSM crystals are formed on the walls of the centrifuge.  The solution has undergone a reverse-osmosis filtration process before the crystallisation process begins and is highly-pure.  This being said, the more costly distillation process is regarded as the gold-standard.

How pure is MISMO MSM?

Every batch of our MSM is rigourously tested by an independent laboratory to ensure the highest possible quality with no additives or anti-caking agents. MSM is gluten free and vegan / vegetarian. Packaged in Australia from imported ingredients.

    How much MISMO MSM should I be taking?

    Start with 1/4 - 1/2 tsp per day (or 1-2 capsules). This is to prevent potential detox side effects (headache or nausea). These are easily avoided with a low start dosage and adequate hydration. 

    After one week, start slowly increasing to the average dose of 2 to 6 grams daily (or 5-6 capsules). Most people take a teaspoon (approx. 4 grams) daily. If more relief is needed, increase the dose slowly. Can be taken in water or juice after breakfast, although there are no rules as to when you should take MSM.

    It is recommended to take MSM in the morning, as it can give a boost of energy. Side effects when starting out with MSM can be nausea and/or headaches. This is not uncommon and is linked to the detoxifying benefits of MSM. We recommend lowering your dose if experiencing these symptoms and gradually increasing with time.

    WARNINGS: If taking strong blood thinners, do not take MSM without your doctor's approval. Not to be taken by children without a health professional's advice.  MSM can also interfere with the accuracy of the blood test for liver enzymes by sometimes producing false positive results. It is recommended you cease taking MSM at least 4 days before these blood tests. You can resume after the test.

    Is MISMO MSM listed with the TGA (Therapeutic Goods Administration)?

    Yes, click here to view the TGA listing for MISMO MSM

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