Which is it? Sodium Hyaluronate or Hyaluronic Acid?

Which is it? Sodium Hyaluronate or Hyaluronic Acid?

In today's skincare market, we are enticed to purchase skincare from numerous sources - pharmacies, department stores, not to mention the allure of social media and online promotions. So how do we tease apart the endless options to be getting the best value for our skin (and wallet?).
The simplest and easiest way is by comparing the ingredients and where they sit on the ingredient listing, as well as an understanding of their chemistry and the delivery system of the formula. Furthermore, each ingredient can be represented with a variety of names, so understanding ingredient terminology is also important as a slightly different name could mean a different chemical structure. One such ingredient is Hyaluronic Acid versus Sodium Hyaluronate. How do they differ? What are their benefits? And how are they used in skincare?
Hyaluronic acid is a natural component found in the body, especially in the skin and connective tissues. It plays a critical role in attracting and maintaining the skin's moisture, and as such, can be found in a wide range of skincare products.
Sodium Hyaluronate, on the other hand, is a derivative of hyaluronic acid, and while both are similar in terms of benefits, there are key differences between the two.


Sodium hyaluronate is a sodium salt that's been synthesized to form smaller molecules for stability and oxidation resistance. This smaller molecule weight enables greater penetration and hydration at deeper levels. It is used in various forms for medicinal purposes as well as cosmetic skincare products and is particularly useful when included in an active serum formulation.

Skin care uses

If you look closely, you will often find sodium hyaluronate as a key ingredient in a range of skincare products such as creams, gels, lotions, and serums. It is a powerful ingredient as it offers superior hydration by drawing in moisture to deeply hydrate and plump the skin, and support collagen integrity.

Eyes, Body, and Healthcare

In addition to skincare products, sodium hyaluronate also plays a role in treating several medical conditions and is a primary ingredient for the following health conditions:

  • Dry Eyes: Hyaluronate is often used in eye drops to help lubricate and soothe dry eyes.

  • Osteoarthritis: In cases where the synovial fluid has deteriorated in joints due to arthritic conditions or wear and tear, injecting sodium hyaluronate into the joints can help lubricate and cushion joints, reducing pain.

  • Cystitis: Sodium hyaluronate can be used as an intravesical treatment for interstitial cystitis. The solution coats the lining of the bladder to significantly reduce pain and improve the quality of life.


The main differences between sodium hyaluronate and hyaluronic acid are that the former has a smaller molecular weight and is water-soluble, allowing for deeper penetration and greater moisture retention. While both provide similar benefits, this difference in molecular weight results in different mechanisms of action.

Sodium hyaluronate works deep within the layers of the skin to hydrate, while hyaluronic acid, which often has a larger molecular size, is better suited to protect the surface skin from water loss. Both support collagen via increased water retention, enabling collagen to stretch without breaking.

Another difference is that sodium hyaluronate is less susceptible to oxidation, making it more stable. This is an important consideration, particularly when it is introduced through an active serum. Both are found within skincare products and are prized for their hydrating, plumping, and anti-aging benefits. 

Sodium hyaluronate offers multiple skincare benefits, working wonders to plump up and revitalize the skin, combat the signs of aging, and support overall skin health. Here are some of its unique advantages:

Oily and Problematic Skin

With its small molecular size, sodium hyaluronate is less prone to clogging, making it an ideal hydrating solution for oily and problematic skin conditions. It effectively boosts hydration, penetrating the deeper layers of the skin between connective tissues, absorbing and retaining moisture. This action eliminates dryness and flaking, improves skin firmness, and reduces the appearance of fine lines and wrinkles.

In a study examining the effects of creams, serums, and lotions containing sodium hyaluronate, researchers observed significantly hydrated, smoothed, and elastic skin at 2, 4, and 8 weeks of treatment. The link between smaller molecular weight and greater hydration was confirmed by the researchers.

Smooths Wrinkles and Fine Lines

Sodium hyaluronate, a powerful humectant, draws and retains moisture within the skin, preventing the formation of future lines. Proven to be an effective anti-aging treatment, a study examining various types of hyaluronic acid found that the low molecular weight of sodium hyaluronate improved both skin moisture and elasticity while significantly reducing wrinkle depth.


We all know acne conditions can pose a lot of problems and are notoriously difficult to treat. Many people with acne-prone skin are typically using one or more medicated skincare products to treat their symptoms. Unfortunately a side effect of these can be dry and irritated skin. This may cause an overproduction of oil, in turn causing more breakouts. Sodium hyaluronate is considered safe for all skin types and is non-comedogenic, ensuring it won't clog pores.

Companion Ingredients to Sodium Hyaluronate

Products that feature sodium hyaluronate as their primary ingredient often incorporate additional ingredients to achieve optimal results. This is because the hydrating effects of sodium hyaluronate can be enhanced through the introduction of other beneficial ingredients, such as:

  • Peptides: Peptides also possess water-binding properties, complementing the hydrating capabilities of sodium hyaluronate.

  • Glycerin: Glycerin is an excellent moisturizing ingredient known for enhancing hydration levels.

  • Hyaluronic Acid: Hyaluronic acid, while similar to sodium hyaluronate, works on the surface level to draw in moisture and prevent water loss, complementing the deeper action of sodium hyaluronate.

  • Vitamin A: Vitamin A is included for its anti-aging and collagen-boosting benefits.

  • Vitamin C: Vitamin C is incorporated for its anti-aging and wound-healing properties.

  • Vitamin E: Vitamin E is added to nourish and protect the skin.

By combining these companion ingredients, skincare products can offer a comprehensive approach to hydration, anti-aging, and overall skin health, providing users with a well-rounded and effective skincare experience.


Sodium Hyaluronate is a synthesised, salt form of hyaluronic acid. While it can provide the same benefits, the mechanism by which it works is different. Due to its much smaller molecular weight, sodium hyaluronate is able to deeply penetrate the skin unlike hyaluronic acid. 

It attracts and binds to water, which allows moisture levels to be maintained in the deeper layers of the skin. This allows hydration of the top layers, supporting collagen and effectively forms and strengthens the skin, plumping and improving the look of fine lines.

While both are similar, if you are seeking deeper penetration we recommend sodium hyaluronate as due its ability to give better results from its size and stability as an active ingredient. At MISMO we only use sodium hyaluronate, which can be found in these products;

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MISMO MSM - 440g / Ultra-Pure Distilled - Pain Relief
MISMO MSM - Pain Relief
MISMO MSM - Capsules / Ultra-Pure Distilled - Pain Relief
MSM capsules pain relief
MISMO MSM - 440g / Pure Crystalline - Pain Relief
MISMO MSM - 850g Ultra-Pure Distilled - Pain Relief
MISMO MSM - 850g/ Pure Crystalline - Pain Relief
MISMO MSM - 2kg Ultra-Pure Distilled - Pain Relief
MISMO MSM - 2kg / Pure Crystalline - Pain Relief
MISMO MSM - Capsules / Ultra-Pure Distilled - Pain Relief
MISMO MSM - Capsules/ Ultra-Pure Distilled - Pain Relief


Sale price$38.00 AUD
Tax included. Shipping free over A$150 (see conditions below).

What is MSM?

MSM (Methyl Sulphonyl Methane or Dimethyl Sulfone) is an organic sulphur compound found in all living organisms. It is the purest and most bio-available form of sulphur, one of the essential minerals crucial to life and the regeneration of cells. MSM has traditionally been taken as a food supplement to increase joint health for flexibility and mobility, as well as for strong hair and nails, beautiful skin, and other health conditions from leaky gut syndrome to mild arthritis, osteoporosis, and psoriasis. 

Why do we need to supplement with MSM?

Natural MSM is largely destroyed when our food is processed and can be lost entirely when foods and ingredients are stored for a long period of time. MSM bonds with moisture, so any food which undergoes any sort of dehydration will lack its natural MSM.

For these reasons, and because MSM is so critical for almost every athletic function in active bodies, it is important to consistently supplement with a quality MSM nutritional supplement 

What is the science of MSM?

Sulphur is integral to the production of collagen and elastin, and MSM is a source of organic Sulphur. Collagen is the principal structural protein holding the skin together and is largely responsible for the skin’s mechanical properties.  Approximately half of the body's sulphur content is found in the skin, muscles, cartilage and bones.

Click here for more information on The Science of MSM

How can MSM benefit your skin, hair and nails?

  • Protecting collagen against collagen degrading enzymes
  • Reducing fine lines and wrinkles by boosting collagen and elastin production
  • Boosting the natural production of Glutathione, one of the body's key anti-oxidants ... as an anti-oxidant, MSM will boost the immune system and reduce pigmentation and cellular damage
  • Acting as an anti-inflammatory agent by reducing the production of cytokines (compounds that cause inflammation)
  • Maintaining skin cell membrane flexibility and permeability, promoting an efficient exchange of nutrients and waste products to help keep skin clear
  • Helping to maintaining the body's pH balance

How can MSM help with joint health and support? 

MSM has powerful anti-inflammatory properties and can be used as a natural alternative to help reduce pain from mild arthritis and osteoarthritis related symptoms.

How does MISMO MSM help with exercise recovery?

Our muscles, skin, bones, organs, and connective tissue all rely on sulphur and without it our bodies can not function properly.  MSM is an important nutritional supplement for anyone living an active lifestyle, as it delivers the sulphur and methyl nutrients which are key to the structure of healthy cells in muscle and connective tissue.

MSM is valued by bodybuilders, strength, and power athletes because it supports healthy and flexible cell structures and can help reduce the inflammation of muscle tissue and can offset muscle soreness and joint pain caused by inflammation.

Where is MSM found and how is it manufactured?

MSM is found in the fluid and tissue of all living organisms. It is present in a variety of foods including raw vegetables, eggs, milk and fish, but is lost through cooking and food processing. One of the richest natural supplies is pine trees and cabbage.

Although MSM is abundant in nature, even the richest natural sources only provide MSM in the level of several parts per million. Commercial extraction of MSM from trees is not possible so a process is undertaken which parallels the natural oxidation that occurs in the marine atmosphere and produces MSM that is a chemical compound identical to that found in nature.

Click here for a detailed explanation of how MSM is manufactured.

What is the difference between Distilled Ultra-Pure MSM and Pure-Crystalline MSM?

With the distilled product, the MSM solution is heated up to a point where the MSM is released as a vapour and the pure crystals are formed and harvested as the vapour cools on the inside surface of a distillation column.  The heating-up of the MSM solution and the subsequent cooling and harvesting process requires a lot more energy, and hence the reason why the price is a bit higher.

With the crystalline product, the MSM solution is "spun" at super-high speed in a centrifuge and the MSM crystals are formed on the walls of the centrifuge.  And although the MSM solution is highly-pure before the crystallisation process begins (having undergone a reverse-osmosis filtration process), there is a remote possibility that if there are any trace impurities in the solution they can become encapsulated in the crystalline structure.

How pure is MISMO MSM?

Every batch of our MSM is rigourously tested by an independent laboratory to ensure the highest possible quality with no additives or anti-caking agents. MSM is gluten free and vegan / vegetarian. Packaged in Australia from imported ingredients.

    How much MISMO MSM should I be taking?

    An average dose is between 2 to 6 grams daily. Most people take a teaspoon (approx. 4 grams) daily. If more relief is needed, increase the dose slowly. Can be taken in water or juice after breakfast, although there are no rules as to when you should take MSM.

    It is recommended to take MSM in the morning, as it can give a boost of energy. Side effects when starting out with MSM can be nausea and/or headaches. This is not uncommon and is linked to the detoxifying benefits of MSM. We recommend lowering your dose if experiencing these symptoms and gradually increasing with time.

    WARNINGS: If taking strong blood thinners, do not take MSM without your doctor's approval. Not to be taken by children without a health professional's advice.  MSM can also interfere with the accuracy of the blood test for liver enzymes by sometimes producing false positive results. It is recommended you cease taking MSM at least 4 days before these blood tests. You can resume after the test.

    Is MISMO MSM listed with the TGA (Therapeutic Goods Administration)?

    Yes, click here to view the TGA listing for MISMO MSM


      Customer Reviews

      Based on 301 reviews
      Joan Wakely

      Great service

      Tabatha Turner
      Pain free!

      I recently discovered i might have Endo and am booked in for all the relevant tests. I started taking MSM two weeks before my cycle and when it hit, the pain was halved if not completely gone. I am in shock! I am going to test it out for another cycle to see if it was the reason, however after some research I can already see that it greatly helps with endo. World changing!

      Kay Blair

      I am really pleased with my orders from mismo especially the msm thank you for great products

      This is just what I need

      MISMO MSM does help! We take it daily.

      Ruth Dyer
      Great stuff

      I have been taking MSM for many years now, and it certainly keeps my arthritis under control.