Which is it? Sodium Hyaluronate or Hyaluronic Acid?

Which is it? Sodium Hyaluronate or Hyaluronic Acid?

In today's skincare market, we are enticed to purchase skincare from numerous sources - pharmacies, department stores, not to mention the allure of social media and online promotions. So how do we tease apart the endless options to be getting the best value for our skin (and wallet?).
The simplest and easiest way is by comparing the ingredients and where they sit on the ingredient listing, as well as an understanding of their chemistry and the delivery system of the formula. Furthermore, each ingredient can be represented with a variety of names, so understanding ingredient terminology is also important as a slightly different name could mean a different chemical structure. One such ingredient is Hyaluronic Acid versus Sodium Hyaluronate. How do they differ? What are their benefits? And how are they used in skincare?
Hyaluronic acid is a natural component found in the body, especially in the skin and connective tissues. It plays a critical role in attracting and maintaining the skin's moisture, and as such, can be found in a wide range of skincare products.
Sodium Hyaluronate, on the other hand, is a derivative of hyaluronic acid, and while both are similar in terms of benefits, there are key differences between the two.

WHAT IS SODIUM HYALURONATE?

Sodium hyaluronate is a sodium salt that's been synthesized to form smaller molecules for stability and oxidation resistance. This smaller molecule weight enables greater penetration and hydration at deeper levels. It is used in various forms for medicinal purposes as well as cosmetic skincare products and is particularly useful when included in an active serum formulation.

Skin care uses

If you look closely, you will often find sodium hyaluronate as a key ingredient in a range of skincare products such as creams, gels, lotions, and serums. It is a powerful ingredient as it offers superior hydration by drawing in moisture to deeply hydrate and plump the skin, and support collagen integrity.

Eyes, Body, and Healthcare

In addition to skincare products, sodium hyaluronate also plays a role in treating several medical conditions and is a primary ingredient for the following health conditions:

  • Dry Eyes: Hyaluronate is often used in eye drops to help lubricate and soothe dry eyes.

  • Osteoarthritis: In cases where the synovial fluid has deteriorated in joints due to arthritic conditions or wear and tear, injecting sodium hyaluronate into the joints can help lubricate and cushion joints, reducing pain.

  • Cystitis: Sodium hyaluronate can be used as an intravesical treatment for interstitial cystitis. The solution coats the lining of the bladder to significantly reduce pain and improve the quality of life.

REVIEWING THE DIFFERENCE BETWEEN HYALURONIC ACID AND SODIUM HYALURONATE

The main differences between sodium hyaluronate and hyaluronic acid are that the former has a smaller molecular weight and is water-soluble, allowing for deeper penetration and greater moisture retention. While both provide similar benefits, this difference in molecular weight results in different mechanisms of action.

Sodium hyaluronate works deep within the layers of the skin to hydrate, while hyaluronic acid, which often has a larger molecular size, is better suited to protect the surface skin from water loss. Both support collagen via increased water retention, enabling collagen to stretch without breaking.

Another difference is that sodium hyaluronate is less susceptible to oxidation, making it more stable. This is an important consideration, particularly when it is introduced through an active serum. Both are found within skincare products and are prized for their hydrating, plumping, and anti-aging benefits. 

Sodium hyaluronate offers multiple skincare benefits, working wonders to plump up and revitalize the skin, combat the signs of aging, and support overall skin health. Here are some of its unique advantages:

Oily and Problematic Skin

With its small molecular size, sodium hyaluronate is less prone to clogging, making it an ideal hydrating solution for oily and problematic skin conditions. It effectively boosts hydration, penetrating the deeper layers of the skin between connective tissues, absorbing and retaining moisture. This action eliminates dryness and flaking, improves skin firmness, and reduces the appearance of fine lines and wrinkles.

In a study examining the effects of creams, serums, and lotions containing sodium hyaluronate, researchers observed significantly hydrated, smoothed, and elastic skin at 2, 4, and 8 weeks of treatment. The link between smaller molecular weight and greater hydration was confirmed by the researchers.

Smooths Wrinkles and Fine Lines

Sodium hyaluronate, a powerful humectant, draws and retains moisture within the skin, preventing the formation of future lines. Proven to be an effective anti-aging treatment, a study examining various types of hyaluronic acid found that the low molecular weight of sodium hyaluronate improved both skin moisture and elasticity while significantly reducing wrinkle depth.

WHAT ABOUT ACNE SKIN?

We all know acne conditions can pose a lot of problems and are notoriously difficult to treat. Many people with acne-prone skin are typically using one or more medicated skincare products to treat their symptoms. Unfortunately a side effect of these can be dry and irritated skin. This may cause an overproduction of oil, in turn causing more breakouts. Sodium hyaluronate is considered safe for all skin types and is non-comedogenic, ensuring it won't clog pores.

Companion Ingredients to Sodium Hyaluronate

Products that feature sodium hyaluronate as their primary ingredient often incorporate additional ingredients to achieve optimal results. This is because the hydrating effects of sodium hyaluronate can be enhanced through the introduction of other beneficial ingredients, such as:

  • Peptides: Peptides also possess water-binding properties, complementing the hydrating capabilities of sodium hyaluronate.

  • Glycerin: Glycerin is an excellent moisturizing ingredient known for enhancing hydration levels.

  • Hyaluronic Acid: Hyaluronic acid, while similar to sodium hyaluronate, works on the surface level to draw in moisture and prevent water loss, complementing the deeper action of sodium hyaluronate.

  • Vitamin A: Vitamin A is included for its anti-aging and collagen-boosting benefits.

  • Vitamin C: Vitamin C is incorporated for its anti-aging and wound-healing properties.

  • Vitamin E: Vitamin E is added to nourish and protect the skin.

By combining these companion ingredients, skincare products can offer a comprehensive approach to hydration, anti-aging, and overall skin health, providing users with a well-rounded and effective skincare experience.

WHICH IS BETTER?

Sodium Hyaluronate is a synthesised, salt form of hyaluronic acid. While it can provide the same benefits, the mechanism by which it works is different. Due to its much smaller molecular weight, sodium hyaluronate is able to deeply penetrate the skin unlike hyaluronic acid. 

It attracts and binds to water, which allows moisture levels to be maintained in the deeper layers of the skin. This allows hydration of the top layers, supporting collagen and effectively forms and strengthens the skin, plumping and improving the look of fine lines.

While both are similar, if you are seeking deeper penetration we recommend sodium hyaluronate as due its ability to give better results from its size and stability as an active ingredient. At MISMO we only use sodium hyaluronate, which can be found in these products;


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MISMO MSM - 440g / Ultra-Pure Distilled - Pain Relief
MISMO MSM - Pain Relief
MISMO MSM - Capsules / Ultra-Pure Distilled - Pain Relief
MSM capsules pain relief
MISMO MSM - 440g / Pure Crystalline - Pain Relief
MISMO MSM - 850g Ultra-Pure Distilled - Pain Relief
MISMO MSM - 850g/ Pure Crystalline - Pain Relief
MISMO MSM - 2kg Ultra-Pure Distilled - Pain Relief
MISMO MSM - 2kg / Pure Crystalline - Pain Relief
MISMO MSM - Capsules/ Ultra-Pure Distilled - Pain Relief
MISMO MSM - Capsules / Ultra-Pure Distilled - Pain Relief

MISMO MSM

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Benefits

  • Supports joint health and movement – Encourages flexibility and mobility for an active lifestyle.
  • Promotes strong cartilage and connective tissue – Provides essential sulfur to maintain joint integrity.
  • Boosts skin hydration and elasticity – Helps support collagen production for smoother, healthier-looking skin.
  • Encourages strong hair and nails – Contributes to hair strength and reduces brittleness.
  • Assists with post-exercise recovery – Supports muscle and tissue repair after physical activity.
  • Supports digestive function – Helps maintain overall gut health and nutrient absorption.

Why It Works

MSM is a natural source of sulfur, an essential nutrient involved in collagen formation, connective tissue maintenance, and overall recovery. Since modern food processing reduces sulfur levels in our diets, supplementing with MISMO MSM helps replenish these vital nutrients for long-term well-being.

Who is it for?

Individuals looking to support joint flexibility and movement, skin hydration, strong hair and nails, and overall wellness.

How MSM Supports an Active, Healthy Lifestyle

  • Joint & Mobility Support: Provides essential sulfur for maintaining joint comfort and flexibility.

  • Skin, Hair & Nail Nourishment: Helps protect collagen and contributes to stronger, more resilient hair and nails.

  • Post-Exercise Recovery: Assists in muscle and tissue support after workouts to help you feel refreshed.

Many people who include MSM in their daily routine report feeling more comfortable and active.

Active Ingredient

  • 100% MSM (Methylsulfonylmethane) – A bioavailable, ultra-pure form of sulfur that supports joints, skin, and connective tissue.

  • Packaged in Australia from imported ingredients. Vegan, gluten-free, and free from additives or anti-caking agents.

How to Use

MSM should be taken daily, and results should not be expected immediately. The recommended daily dose is 2–6 grams.

  • Start slow: Take ¼–½ teaspoon daily (or 1–2 capsules) and allow your body to adjust.
  • Increase gradually: After a week, increase to 1 teaspoon daily (or up to 6 capsules), based on your needs.
  • Best taken in the morning: Many users find it provides a natural boost when mixed with water or juice.

Some people experience mild detox effects when starting MSM, like slight headaches. If this happens, just lower your dose and gradually increase it. This is a sign that MSM is working.

MSM with Vitamin C and Collagen

Pairing MSM with Vitamin C and Collagen can help absorption and effectiveness. Vitamin C plays a key role in collagen production, which, when combined with MSM, helps support joint health, skin elasticity, and overall well-being. Many people take these together as part of their daily routine to support healthy aging, mobility, and skin vitality.

MISMO Vitamin C Powder

MISMO Marine Collagen Peptides

MSM with Magnesium

MSM and Magnesium also work together to support muscle recovery, joint health, and overall well-being. MSM helps with flexibility and inflammation support, while Magnesium plays a key role in muscle relaxation and nerve function. Many people take them together to help with muscle tension, post-workout recovery, and overall mobility. Pairing MSM with Magnesium can be a great way to support an active lifestyle and daily comfort.

MISMO Magnesium

Wellness Bundle

Capsules or Powder?

  • MSM Powder – Best for daily use at home and most cost-effective for everyday use.

  • MSM Capsules – A convenient travel-friendly option, or for those who prefer to avoid the natural taste of MSM.

How to add MSM to your daily Routine

MSM has a naturally strong taste that some people find bitter, but it can be easily blended with other flavors to make it more enjoyable. Here are some simple ways to incorporate it into your routine:

  • Morning Smoothie: Blend into your favorite smoothie with fruits and greens for a nutritional boost.
  • Refreshing Detox Drink: Stir into warm lemon water to start your morning feeling refreshed.
  • Daily Wellness Blend: Add to your collagen supplement or protein shake to support overall well-being.
  • Post-Workout Support: Mix into a recovery drink to complement your fitness routine.
  • Herbal Tea Addition: Pair with chamomile or ginger tea as part of your evening wind-down.
  • Beauty Tonic: Combine with aloe vera juice as part of your skin, hair, and nail care routine.
  • Pre-Workout Hydration: Stir into your electrolyte drink before exercise.
  • Bone Broth Infusion: Add to bone broth for an extra source of naturally occurring sulfur.
  • DIY Face Mask: Mix with water for a topical application—always patch test and consult a dermatologist if unsure.
  • Daily Ritual: Pair with turmeric and ginger as part of a balanced lifestyle.

Finding a way to take MSM that works for you makes it easier to enjoy the benefits daily.

Quality & Purity

MISMO MSM is tested for purity and quality to ensure you receive a clean, bioavailable supplement with zero additives or fillers. Click here for infomation on how MSM is manufactured.

What Makes MSM Essential?

Sulfur is a key component of collagen, elastin, and connective tissues, helping to maintain joint mobility, skin resilience, and overall well-being. MSM provides a natural, highly absorbable form of sulfur to support your body's daily needs.

Click here for more information on The Science of MSM

Regulatory Information

MISMO’s MSM Powder is registered with the Australian Register of Therapeutic Goods (ARTG) as a listed medicine. Our product complies with all relevant safety, quality, and efficacy standards set by the Therapeutic Goods Administration (TGA).

Product Disclaimer

This product is not intended to diagnose, treat, cure, or prevent any disease. Always read the label and follow the directions for use. If symptoms persist, talk to your health professional.

The information provided by MISMO is general in nature and not intended to be a substitute for professional medical advice. Please consult your doctor or qualified healthcare provider if you have any questions about your health, medications, or supplementation needs.

Do not take MSM if you are currently using prescription blood thinners or have known sensitivities, unless under the guidance of your healthcare provider. Not recommended for children without professional advice. Discontinue use if any adverse reaction occurs.

Learn more about MISMO MSM

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